Colonel Dr. Sam Daniels has just divorced his wife Robby Keough, who works at the CDC. Out of the blue, he is assigned by his superior General Billy Ford to investigate a lethal disease in an African village with his crew formed by the scientist Casey Schuler and Major Dr. Salt. They are impressed by the disease and Colonel Daniels reports to General Ford his findings afraid of contamination in the USA. However General Ford tells that the disease kills so fast that would never reach their country. However, an African smuggled monkey carrier of the disease is brought to USA and the customs employee Jimbo Scott unsuccessfully tries to sell the animal. He releases the monkey in the woods and spreads the disease in the beginning of an outbreak in a small town in California. Now Colonel Daniels, his ex-wife and their teams must fight the invisible enemy while Colonel Daniels discovers dark secrets from his superior General Donald McClintock.