Josh's first assignment in his creative writing program is to write a typed report/paper about his greatest adventure. Meanwhile Drake and Josh's parents leave to go on a ten-day cruise, leaving Drake and Josh in charge. But when Drake and Josh accidentally reverse the flight number, sending her to Los Angeles International Airport (flight 647) instead of Denver. Her brothers find out the mistake and follow her on another plane. Upon arriving in Los Angeles, Megan uses her parents' credit card to order a limousine to take her to an expensive hotel and book a presidential suite. Before finding out, however, the brothers wait to see Megan's plane take off. When the brothers arrive in Los Angeles, they go out to find their sister and get her to Denver. At this moment, several criminals enter the suite and attempt to take the G-O. It's up to Drake and Josh to foil the bad guys, and get to the TRL studio in time.